营销话术证据 A · 指南级
氨基葡萄糖治膝痛
真相
大型试验 GAIT(2006)的主要结果是阴性的,没看到效果;中重度疼痛那一组的信号,也没通过事先设定的检验。
这话术为什么会流行
几十年来最舍得打广告的关节补剂之一;早期小研究加上“直接补软骨”这种直觉叙事,让它在更大的试验之后仍长盛不衰。
机制速览
氨基葡萄糖(也叫葡萄糖胺,药店常说的氨糖)和软骨素,是中老年人护膝盖、缓解关节痛最常买的两种补剂。它们确实是关节软骨的原料,但吃下去能不能补到膝盖,是另一回事。
来源(1)
- Clegg, D. O., Reda, D. J., Harris, C. L., Klein, M. A., O'Dell, J. R., Hooper, M. M., et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine, 354(8), 795-808. 1,583 patients, 24 weeks: glucosamine 1,500 mg, chondroitin 1,200 mg, both, celecoxib 200 mg or placebo. Response (>= 20% pain reduction) with placebo 60.1%; glucosamine +3.9 points (P = 0.30), chondroitin +5.3 (P = 0.17), combination +6.5 (P = 0.09), celecoxib +10.0 (P = 0.008). Assignment was stratified by pain severity (mild n = 1,229; moderate to severe n = 354); in the moderate-to-severe stratum the combination responded 79.2% vs 54.3% (P = 0.002), which the authors call exploratory (abstract, PMID 16495392).