营销话术证据 A · 指南级
他汀耗光 CoQ10，补 CoQ10 能治他汀肌肉痛
真相
他汀确实会减少辅酶 Q10（甲羟戊酸通路），但汇总 6 项随机试验、302 人的分析显示，补辅酶 Q10 不能可靠缓解肌肉痛（Banach 2015）。
机制速览
两个对照的例子，能帮你分清该补和该错开时间。
来源（2）
- Wiesner, A., Gajewska, D., & Pasko, P. (2021). Levothyroxine interactions with food and dietary supplements - a systematic review. Pharmaceuticals, 14(3), 206. Calcium, iron, and coffee reduce levothyroxine absorption. Coffee (Benvenga 2008): average T4 rise 36% lower in patients and 29% in volunteers, peak 30% and 19%; coffee 1 h after the dose made no difference. Iron: TSH rises in case reports and cohorts, no absorption percentage. Advises food 30-60 min after the dose, calcium and iron 2-4 h after, coffee 1 h after.
- Banach, M., Serban, C., Sahebkar, A., et al. (2015). Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clinic Proceedings, 90(1), 24-34. Across 6 RCTs (302 patients), CoQ10 supplementation produced no significant improvement in statin-associated muscle pain or plasma creatine kinase. CK: 5 studies (226 participants), mean difference 11.69 U/L, P = .38; muscle pain: 5 studies (253 participants), no significant effect despite a trend; no dose-effect association (abstract, PMID 25440725).