尿石素 A · 菌把石榴变成线粒体标签

参考文献 · 3

1. Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Felix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., Aebischer, P., Sandi, C., Rinsch, C., & Auwerx, J. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22(8), 879-888. First-in-class natural compound that induces mitophagy in vitro and in vivo after oral intake. In C. elegans it limited age-related accumulation of dysfunctional mitochondria and extended lifespan; in rodents it improved exercise capacity. 10.1038/nm.4132
2. Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., Auwerx, J., Singh, A., & Rinsch, C. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 1(6), 595-603. First-in-human trial in sedentary elderly: UA was bioavailable; 4 weeks at 500 mg and 1,000 mg modulated plasma acylcarnitines and skeletal-muscle mitochondrial gene expression. Primary outcome was safety, not strength. 10.1038/s42255-019-0073-4
3. Singh, A., D'Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3(5), 100633. Placebo-controlled, two doses for 4 months (NCT03464500). Hamstring strength rose about 12% at 500 mg vs placebo. Peak power output (primary endpoint) did not improve significantly. Mitopure is a proprietary UA; the paper is industry-affiliated. 10.1016/j.xcrm.2022.100633