糖原超代偿 · 合酶把基线顶过去

参考文献 · 4

1. Bergström, J., & Hultman, E. (1966). Muscle glycogen synthesis after exercise: an enhancing factor localized to the muscle cells in man. Nature, 210(5033), 309-310. One-legged exhaustive exercise then carbohydrate feeding: glycogen overshoot is confined to the exercised leg. The authors' own conclusion is that the enhancing factor is inside those muscle cells, not a circulating whole-body hormone. n is tiny; the load-bearing fact is the contralateral localisation, later replicated. 10.1038/210309a0
2. Jensen, T. E., & Richter, E. A. (2012). Regulation of glucose and glycogen metabolism during and after exercise. The Journal of Physiology, 590(5), 1069-1076. Symposium review: contraction raises glucose transport (GLUT4), glycogen phosphorylase and glycogen synthase are both regulated by covalent and allosteric signals, and glucose-6-phosphate allosterically activates synthase while inhibiting phosphorylase. Post-exercise insulin sensitisation of glucose transport plus synthase activation can produce an overshoot of intramuscular glycogen (supercompensation). Narrative, not a systematic review. 10.1113/jphysiol.2011.224972
3. Hingst, J. R., Bruhn, L., Hansen, M. B., Rosschou, M. F., Birk, J. B., Fentz, J., Foretz, M., Viollet, B., Sakamoto, K., Færgeman, N. J., Havelund, J. F., Parker, B. L., James, D. E., Kiens, B., Richter, E. A., Jensen, J., & Wojtaszewski, J. F. P. (2018). Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle. Molecular Metabolism, 16, 24-34. One-legged glycogen-depleting exercise in humans plus transgenic mouse follow-ups. Glycogen synthase and AMPK stay activated beyond the point where muscle glycogen has returned to the pre-exercise line; the authors' hypothesis is that this offsets the usual feedback inhibition of synthesis and glucose uptake by glycogen. Inducible muscle AMPK deletion, and a glycogen synthase that cannot be allosterically activated by glucose-6-phosphate, both abolish supercompensation. Conclusion in the paper: AMPK and glycogen synthase are both key regulators of supercompensation after a single depleting bout. 10.1016/j.molmet.2018.07.001
4. Sherman, W. M., Costill, D. L., Fink, W. J., & Miller, J. M. (1981). Effect of exercise-diet manipulation on muscle glycogen and its subsequent utilization during performance. International Journal of Sports Medicine, 2(2), 114-118. Three 6-day regimens in trained runners: classic low-then-high carbohydrate, mixed-then-high, and mixed throughout. Muscle glycogen on day 7 reached 207, 203, and 159 mmol glucosyl units/kg wet tissue. The 20.9 km performance run was not faster after the two high-glycogen regimens. The paper's own three conclusions: glycogen can be raised with a moderate exercise-diet regimen; starting glycogen changes how much is used; carbohydrate loading did not help this 20.9 km run. 10.1055/s-2008-1034594