Pantothenic Acid

维生素 B5

Place · Level 3

CoA 的核心部件 · 从脂肪酸到固醇激素 · 无所不在所以缺乏少见

Connected to · 2

cofactor · 2

α-Lipoic Acid
PDH carries both lipoyl and CoA: pyruvate's acetyl is handed by the lipoyl arm to CoA-SH forming acetyl-CoA. Five cofactors, no shortcuts.
Fat Types
B5 is part of CoA; fatty-acid synthesis and oxidation use acyl-CoA carriers.

CoA component

Stop 1/5

CoA 的核心部件

B5 is a key building block of coenzyme A (CoA) — specifically, it makes up the pantetheine segment of CoA, providing the -SH (thiol) group that carries acyl groups.

CoA's main job is to ferry around acyl groups, and the most important one is acetyl-CoA:

The energy convergence point: glucose (pyruvate → acetyl-CoA), fat (beta-oxidation), and some amino acids (which generate acetyl-CoA directly) all converge heretricarboxylic acid (Krebs) cycle: The mitochondrial hub cycle that fully oxidizes fuel and harvests electrons for energy. cycle entry: acetyl-CoA enters the citrate synthase reactionSynthesis precursor: acetyl-CoA is the common starting material for de novo fatty acid synthesis and cholesterol synthesis
B5 is not energy itself — it is the carrier platform at metabolism's central intersection.

Read story Open mechanism

Educational content, not medical advice — consult a clinician.

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Pantothenic Acid

维生素 B5

Place · Level 3

CoA 的核心部件 · 从脂肪酸到固醇激素 · 无所不在所以缺乏少见

Connected to · 2

cofactor · 2

α-Lipoic Acid
PDH carries both lipoyl and CoA: pyruvate's acetyl is handed by the lipoyl arm to CoA-SH forming acetyl-CoA. Five cofactors, no shortcuts.
Fat Types
B5 is part of CoA; fatty-acid synthesis and oxidation use acyl-CoA carriers.

CoA component

Stop 1/5

CoA 的核心部件

B5 is a key building block of coenzyme A (CoA) — specifically, it makes up the pantetheine segment of CoA, providing the -SH (thiol) group that carries acyl groups.

CoA's main job is to ferry around acyl groups, and the most important one is acetyl-CoA:

The energy convergence point: glucose (pyruvate → acetyl-CoA), fat (beta-oxidation), and some amino acids (which generate acetyl-CoA directly) all converge heretricarboxylic acid (Krebs) cycle: The mitochondrial hub cycle that fully oxidizes fuel and harvests electrons for energy. cycle entry: acetyl-CoA enters the citrate synthase reactionSynthesis precursor: acetyl-CoA is the common starting material for de novo fatty acid synthesis and cholesterol synthesis
B5 is not energy itself — it is the carrier platform at metabolism's central intersection.

Read story Open mechanism

Educational content, not medical advice — consult a clinician.