Coenzyme Q10 (Ubiquinone / Ubiquinol)

synergy · 2

• ↔Heart

  In Q-SYMBIO (Mortensen 2014), 420 people with moderate to severe chronic heart failure took CoQ10 100 mg three times a day for 2 years: major adverse cardiovascular events 15% vs 26%; all-cause death 10% vs 18% was a secondary endpoint. It is a small trial, the Cochrane mortality estimate rests on it alone, and no large trial has repeated it. Statins lower blood CoQ10, but a meta-analysis of randomized trials found no benefit of CoQ10 for statin-associated muscle pain (Banach 2015).

  RCT · highREVIEW · highREVIEW · high

• ↔Migraine

  In the Sándor 2005 double-blind randomized trial (42 people), CoQ10 300 mg a day halved attacks or better by month 3 in 47.6% vs 14.4% on placebo. The 2012 guideline of the American Academy of Neurology and American Headache Society rates it possibly effective for prevention, one tier below magnesium and riboflavin (probably effective). It works slowly: it takes months to tell whether it helps.

  RCT · moderateGUIDE · high

depletes · 1

• ↮Drug–Nutrient

  Statins block the mevalonate pathway and lower blood CoQ10 along with it; but a meta-analysis of randomized trials found no benefit of CoQ10 supplements for statin-associated muscle pain (Banach 2015).

  REVIEW · high