Biotin

生物素 B7

Place · Level 3

羧化酶辅因子 · 参与糖异生与脂肪酸合成 · 被头发营销过度消费

Connected to · 3

cofactor · 2

Carbs & Fiber
B7 supports carboxylases linking gluconeogenesis, fatty-acid synthesis, and amino-acid metabolism.
Protein
Biotin is cofactor for MCC and related carboxylases that catalyze branched-chain amino acid (Leu/Ile/Val) catabolism — a hidden BCAA pathway beyond the carbohydrate-metabolism story.

regulates · 1

Hair Loss
Biotin is a carboxylase cofactor and true deficiency does cause hair loss. In people who are not deficient, the extra mostly goes on to interfere with thyroid lab assays, not to grow hair — a marketing favourite.

Carboxylase cofactor

Stop 1/5

羧化酶辅因子

B7 is the shared cofactor for four critical carboxylases — it works by being covalently bound to a lysine residue on the enzyme:

1. Pyruvate carboxylase: pyruvate → oxaloacetate → enters gluconeogenesis (producing glucose during fasting or low-carb states)
2. Acetyl-CoA carboxylase (ACC): acetyl-CoA → malonyl-CoA → the first committed step of de novo fatty acid synthesis; also regulates fatty acid oxidation via malonyl-CoA (which inhibits CPT1)
3. 3-methylcrotonyl-CoA carboxylase (MCC): leucine catabolism
4. Propionyl-CoA carboxylase (PCC): metabolism of odd-chain fatty acids and branched-chain amino acids

These four pathways span glucose metabolism, lipid metabolism, and amino acid metabolism — which is why B7 is such a foundational nutrient.

Read story Open mechanism

Educational content, not medical advice — consult a clinician.

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Biotin

生物素 B7

Place · Level 3

羧化酶辅因子 · 参与糖异生与脂肪酸合成 · 被头发营销过度消费

Connected to · 3

cofactor · 2

Carbs & Fiber
B7 supports carboxylases linking gluconeogenesis, fatty-acid synthesis, and amino-acid metabolism.
Protein
Biotin is cofactor for MCC and related carboxylases that catalyze branched-chain amino acid (Leu/Ile/Val) catabolism — a hidden BCAA pathway beyond the carbohydrate-metabolism story.

regulates · 1

Hair Loss
Biotin is a carboxylase cofactor and true deficiency does cause hair loss. In people who are not deficient, the extra mostly goes on to interfere with thyroid lab assays, not to grow hair — a marketing favourite.

Carboxylase cofactor

Stop 1/5

羧化酶辅因子

B7 is the shared cofactor for four critical carboxylases — it works by being covalently bound to a lysine residue on the enzyme:

1. Pyruvate carboxylase: pyruvate → oxaloacetate → enters gluconeogenesis (producing glucose during fasting or low-carb states)
2. Acetyl-CoA carboxylase (ACC): acetyl-CoA → malonyl-CoA → the first committed step of de novo fatty acid synthesis; also regulates fatty acid oxidation via malonyl-CoA (which inhibits CPT1)
3. 3-methylcrotonyl-CoA carboxylase (MCC): leucine catabolism
4. Propionyl-CoA carboxylase (PCC): metabolism of odd-chain fatty acids and branched-chain amino acids

These four pathways span glucose metabolism, lipid metabolism, and amino acid metabolism — which is why B7 is such a foundational nutrient.

Read story Open mechanism

Educational content, not medical advice — consult a clinician.