GLP-1 drugs do not repair leptin resistance; they bypass the blocked loop and press directly on the downstream POMC neurons. That is why they work for people who have already done the lifestyle work — and why stopping brings the weight back.
Drugs are a real option, not a mark of failure — but the ledger has to be complete: semaglutide 2.4 mg weekly for 68 weeks averages 14.9% loss against 2.4% on placebo, and about two thirds comes back within a year of stopping. This is chronic treatment for a chronic condition, not a course.