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cofactor · 1
→Iron
Red meat supplies heme iron, which the gut absorbs with its porphyrin ring attached, several times more efficiently than non-heme iron and far less affected by tea or phytate, although calcium can lower both kinds. The upside is well-absorbed iron; the other side is that heme may promote oxidative reactions in the gut, which is thought to be one of the mechanisms behind the link between red meat and colorectal cancer.
regulates · 1
The problem with processed and red meat plays out mainly in the colon: N-nitroso compounds from curing, together with the oxidation that heme iron promotes in the gut, are thought to damage the DNA of the cells lining the bowel. The International Agency for Research on Cancer (IARC) classifies processed meat as Group 1 and red meat as Group 2A carcinogens; the grades describe how certain the evidence is, not how large the harm is.