Fish Oil · EPA / DHA Supplement

synergy · 2

• ↔Heart

  Fish-oil clinical benefit depends entirely on actual EPA+DHA dose and baseline TG. The 'fish oil protects the heart' claim is marketing oversimplification; the strongest evidence is for icosapent ethyl in high-TG + high-CV-risk patients.

  RCT · A

• ↔Vitamin D

  The VITAL trial design itself was omega-3 + D co-intervention; overall depression/immune/CV hard endpoints null, but subgroup + exploratory analyses showed signal in low-baseline populations. Clinical: not 'supplement everyone' — combine only when correcting documented deficiency.

  RCT · AREVIEW · A

cofactor · 1

• ↔Fats & Omega-3

  DHA is membrane material, not just an anti-inflammatory: about half the lipid in retinal rod outer segments and 15-20% of brain grey matter, setting membrane fluidity and receptor function. Fetal brain and visual development runs on this.

  REVIEW · A