Curcumin · diferuloylmethane

姜黄素 Curcumin

Place · Level 3 · Supplement

机制清楚 · 但生物利用度 < 1% 是核心 catch · 证据按疾病分层

Connected to · 3

synergy · 1

Fats & Omega-3
Anti-inflammatory stack: curcumin (NF-κB / COX-2 inhibition) + EPA/DHA → pro-resolving eicosanoids (resolvins, protectins). Moderate combined evidence in chronic inflammation (RA, IBD, NAFLD); weak monotherapy.

regulates · 1

Heart
Curcumin does carry an anti-inflammatory signal, but much of its in-vitro 'treats everything' performance comes from it being an assay-interfering compound, on top of very poor oral absorption. As the mainstay of an anti-inflammatory cardiovascular plan, the magnitude is wrong.

contrast · 1

Milk Thistle
The same bioavailability predicament: both act in a dish, while poor absorption plus rapid phase II conjugation after swallowing leaves free active compound far below experimental concentrations.

姜黄素 Curcumin

Place · Level 3 · Supplement

机制清楚 · 但生物利用度 < 1% 是核心 catch · 证据按疾病分层

Connected to · 3

synergy · 1

Fats & Omega-3
Anti-inflammatory stack: curcumin (NF-κB / COX-2 inhibition) + EPA/DHA → pro-resolving eicosanoids (resolvins, protectins). Moderate combined evidence in chronic inflammation (RA, IBD, NAFLD); weak monotherapy.

regulates · 1

Heart
Curcumin does carry an anti-inflammatory signal, but much of its in-vitro 'treats everything' performance comes from it being an assay-interfering compound, on top of very poor oral absorption. As the mainstay of an anti-inflammatory cardiovascular plan, the magnitude is wrong.

contrast · 1

Milk Thistle
The same bioavailability predicament: both act in a dish, while poor absorption plus rapid phase II conjugation after swallowing leaves free active compound far below experimental concentrations.