Place · Level 3
累 不是诊断, 是症状——同一个词底下藏着好几种不同的短缺; 分清层次、一项项排查, 比堆抗疲劳补剂管用。ME/CFS 的标志是用力后崩溃, Long COVID 又把这条线拉长了一截。
cofactor · 1
Inadequate protein is the item most often skipped on a fatigue work-up; the people at risk are older adults and long-term dieters. Short of protein, muscle gets used as raw material and both strength and stamina fall together.
regulates · 6
The first month of a fatigue work-up is about finding reversible causes, and obstructive sleep apnoea is the one most often missed — screen it and treat it before supplementing anything.
B12 deficiency is a standard stop on a fatigue work-up, and the high-risk groups are easy to name: older adults, vegans, long-term metformin or PPI users. Found and corrected, it belongs to the reversible layer, not to chronic fatigue.
Hypothyroidism is a standard stop on the fatigue work-up: found and corrected with levothyroxine, it belongs to the reversible layer rather than being filed as chronic fatigue.
The first month of a chronic-fatigue work-up is crossing off reversible causes one at a time, and insomnia is one of them: found, it goes to CBT-I rather than the tiredness being filed as the diagnosis.
A 25(OH)D under 20 ng/mL is worth checking and correcting in a fatigue work-up — but pushing past sufficiency buys no more energy, and that is the direction people usually get wrong.
Folate and B12 deficiency need checking together on the fatigue line: their haematology looks alike, and folate alone masks the anaemia of B12 deficiency while neurological damage carries on behind a normal blood count.