1 · Two curves · two upstream signals
The cycle is a relay from hypothalamus to pituitary to ovary to endometrium: the pituitary releases and , and the ovary answers with and progesterone.The cycle is not the uterus performing alone — it is a hypothalamus → pituitary → ovary → endometrium relay. Upstream the pituitary releases and ; downstream the ovary answers with two main curves — (E2) and progesterone (P).The x-axis is one standard 28-day cycle (counting from Day 1 of menses). Remember the shape of these two lines — the next three steps all happen on them.