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synergy · 1
Maximal oxygen uptake (VO2max) is set by three stages: how much blood the heart pumps per minute, how much oxygen the blood carries, and how much oxygen the muscles can extract. Mandsager 2018 looked back at more than 120,000 people who had a treadmill exercise test: the elite-fitness group had about one fifth the all-cause death risk of the lowest-fitness group. This is an association and does not prove that raising fitness adds years.
regulates · 2
Setting Zone 2 as a percentage of maximum heart rate has a problem: the 220-minus-age formula is itself off by ±10–12 beats per minute for an individual. So a simple test, being able to speak in full sentences but not sing, is often more reliable than the heart-rate number on your watch.
Skipping cardio for fear of losing muscle is a bad trade. In a cohort of more than 100,000 people, those with low cardiorespiratory fitness had about five times the all-cause death rate of those with high fitness (an observed association), while the interference cardio causes with strength gains is limited and can be managed through training volume.