加载中…
Place · Level 3
免疫不是变弱而是失调 + 失衡· 胸腺萎缩 → 对新抗原/疫苗应答迟钝 · 炎龄 (Franceschi): 衰老细胞 SASP + 内脏脂肪推高 IL-6/CRP · 拆穿免疫增强剂(更高 ≠ 更好) · 杠杆最大的是疫苗 + 运动 + 蛋白质, 不是补剂
cofactor · 1
Antibodies, complement and immune cells are all built from protein, and older adults need more of it than the young (PROT-AGE puts healthy elderly at about 1.0-1.2 g/kg/day) — plus the exercise to use it. Falling short costs twice: muscle lost and immune raw material short.
depletes · 1
Inflammation and muscle form a loop that turns on its own: inflammation accelerates muscle breakdown, less muscle means less anti-inflammatory capacity, reduced activity adds visceral fat, and inflammation rises again. This is why preserving muscle ranks so high in ageing.
regulates · 4
Inflammaging is the same chronic low-grade inflammation machinery seen through the lens of ageing — one NF-kB to IL-6 to CRP pathway, drifting upward with the years.
The low-grade inflammation of immune ageing is one shared upstream of cognitive decline — not the only cause, but it converges with the vascular and metabolic lines.
Chronic stress accelerates immune ageing through immune dysregulation: sustained cortisol suppresses cell-mediated immunity while pushing low-grade inflammation up. Stress management here is not soft advice — it acts on the same machine.
Two different things: filling a gap is worth doing — correcting a deficiency may marginally help respiratory infection — while topping up someone already sufficient adds nothing. Immunity is not better-when-higher; supplements restore normal, they do not push past it.